Ponawel, the active ingredient of which is ponatinib 45mg, is similar to Iclusig and is its Indian generic. Ponatinib is an anti-tumor (anti-cancer) drug that prevents the growth of cancer cells, which are eventually destroyed by the body. Ponatinib was developed for the effective treatment of chronic myeloid leukemia and acute lymphoblastic leukemia with a positive Philadelphia chromosome. It is a multi-targeted tyrosine kinase inhibitor that is prescribed for patients who have used at least 2 other treatments and have not given a satisfactory result. Ponawel is manufactured in India by Heet.